Vitamin D3
Mechanisms:
Scientific studies:
Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1.
"The serum vitamin D concentration and number of dermal neurofibromas reported by patients with NF1 were inversely correlated (Spearman's rho = -0.572, p<0.00001). The occurrence of low serum vitamin D concentrations in people with NF1, especially those with many dermal neurofibromas, may provide new pathogenic insights and have important therapeutic implications."
High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1.
"NF1 patients display significantly lower 25-(OH)-cholecalciferol serum levels and decreased BMD compared to control individuals....To address the question whether a normalization of calcium homeostasis improves BMD in NF1 patients, we treated four patients with cholecalciferol for 1 year, which resulted in a significant increase of BMD.
CONCLUSION:Taken together, our data provide the first complete histomorphometric analysis from NF1 patients. Moreover, they suggest that low vitamin D levels significantly contribute to the skeletal defects associated with the disease."
(Summary: NF1 patients have significantly lower Vitamin D levels and lower bone mass density. Replacing Vitamin D helps to correct the bone problems.)
"Application of vitamin D3 ointment on the skin, in combination with intense pulsed-radio frequency, may be beneficial in the treatment of pigmented lesions associated with neurofibromatosis 1 (NF1)."--Mayo Clinic
Other articles:
Modest Vitamin D Levels May Decrease Your Risk of ALL Cancer by 77 Percent
This is not always absorbed well through the gut. There are Vitamin D3 creams. Also it's possible to mix it into a natural lotion and apply it through the skin.
This is one of those things that needs to be monitored with blood tests, because both too little and too much Vitamin D can contribute to cancer and health problems. Having it in the middle range is optima.
Helping bone (and tooth) health
"Dr. Kim Hunter Schaedle had this to say on the CTF blog recently. 'People with NF1 seem to metabolize Vitamin D differently than the rest of the population. The result is that individuals with NF1 effectively can have a Vitamin D ‘deficiency’ in the body, even if they are taking normal doses of Vitamin D (in food and supplements). The main negative effect of this is believed to be detrimental effects on bone health. Bone is a tissue that turns over throughout life and it needs Vitamin D to do maintain healthy. The good news is that ongoing studies are pointing to the possibility that individuals with NF1 who take additional high amounts of Vitamin D supplements see a positive effect on bone health. There is no evidence that Vitamin D can be harmful for someone with NF1."--food vitamins etc.
Vitamin D Drops:
Seeking Health Vitamin D3 - pure, cost-effective (900 doses), and drops can be used sublingually or mixed into cream.
Vitamin D deficiency possibly related to dermal tumors:
"Some patients with the most severe dermal tumoring were found to be vitamin D deficient. The reasons for why that is are unknown but the fact that NFers do suffer from other conditions related to vitamin D deficiency is compelling. There is always the possibility that the tumors are feeding off of D. There have been several children on the BB who are hypercalcemic (sensitive to vitamin D) so I would not automatically give a two year old extra D without having his levels checked. I just think its a wise precaution. "--Diet and NF1
Mechanisms:
- Often low in NF
- Anti-tumor
- Decreases NFkB
- Inhibits Ras
- Stimulates p21
- Anti-inflammatory
- Anti-cancer
- Can help mood
Scientific studies:
Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1.
"The serum vitamin D concentration and number of dermal neurofibromas reported by patients with NF1 were inversely correlated (Spearman's rho = -0.572, p<0.00001). The occurrence of low serum vitamin D concentrations in people with NF1, especially those with many dermal neurofibromas, may provide new pathogenic insights and have important therapeutic implications."
High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1.
"NF1 patients display significantly lower 25-(OH)-cholecalciferol serum levels and decreased BMD compared to control individuals....To address the question whether a normalization of calcium homeostasis improves BMD in NF1 patients, we treated four patients with cholecalciferol for 1 year, which resulted in a significant increase of BMD.
CONCLUSION:Taken together, our data provide the first complete histomorphometric analysis from NF1 patients. Moreover, they suggest that low vitamin D levels significantly contribute to the skeletal defects associated with the disease."
(Summary: NF1 patients have significantly lower Vitamin D levels and lower bone mass density. Replacing Vitamin D helps to correct the bone problems.)
"Application of vitamin D3 ointment on the skin, in combination with intense pulsed-radio frequency, may be beneficial in the treatment of pigmented lesions associated with neurofibromatosis 1 (NF1)."--Mayo Clinic
Other articles:
Modest Vitamin D Levels May Decrease Your Risk of ALL Cancer by 77 Percent
This is not always absorbed well through the gut. There are Vitamin D3 creams. Also it's possible to mix it into a natural lotion and apply it through the skin.
This is one of those things that needs to be monitored with blood tests, because both too little and too much Vitamin D can contribute to cancer and health problems. Having it in the middle range is optima.
Helping bone (and tooth) health
"Dr. Kim Hunter Schaedle had this to say on the CTF blog recently. 'People with NF1 seem to metabolize Vitamin D differently than the rest of the population. The result is that individuals with NF1 effectively can have a Vitamin D ‘deficiency’ in the body, even if they are taking normal doses of Vitamin D (in food and supplements). The main negative effect of this is believed to be detrimental effects on bone health. Bone is a tissue that turns over throughout life and it needs Vitamin D to do maintain healthy. The good news is that ongoing studies are pointing to the possibility that individuals with NF1 who take additional high amounts of Vitamin D supplements see a positive effect on bone health. There is no evidence that Vitamin D can be harmful for someone with NF1."--food vitamins etc.
Vitamin D Drops:
Seeking Health Vitamin D3 - pure, cost-effective (900 doses), and drops can be used sublingually or mixed into cream.
Vitamin D deficiency possibly related to dermal tumors:
"Some patients with the most severe dermal tumoring were found to be vitamin D deficient. The reasons for why that is are unknown but the fact that NFers do suffer from other conditions related to vitamin D deficiency is compelling. There is always the possibility that the tumors are feeding off of D. There have been several children on the BB who are hypercalcemic (sensitive to vitamin D) so I would not automatically give a two year old extra D without having his levels checked. I just think its a wise precaution. "--Diet and NF1
